Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

999
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
999
Cancer Vaccines01:30

Cancer Vaccines

434
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
434
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pain and complications during ventrogluteal injection in standing versus lying positions in women: a quasi-experimental crossover study.

Journal of research in nursing : JRN·2026
Same author

Association of nursing error, just culture, and personality type: Health system promotion approach.

Journal of education and health promotion·2026
Same author

Ex vivo evaluation of Newcastle disease virus to enhance natural killer cell function against acute myeloid leukemia cells.

Scientific reports·2026
Same author

Harnessing CAR-NK cells against multiple myeloma: current landscape and future directions.

Molecular biology reports·2026
Same author

Early detection and community-based surveillance of Aedes albopictus in the Razmian region of Qazvin Province, Iran.

Scientific reports·2026
Same author

Integrating Equity in Topic Selection for Orphan Medicinal Products: Policy Implications for Health Technology Assessment in Rare Diseases.

Applied health economics and health policy·2026

Related Experiment Video

Updated: Jul 26, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

888

Cancer immunotherapy via stem cell-derived NK cells.

Fatemeh Hosseini1,2, Mohammad Ahmadvand3,4, Roya Karimi5

  • 1Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran.

Immunotherapy
|June 20, 2023
PubMed
Summary

Natural killer (NK) cells show promise in cancer immunotherapy. This review covers advances in stem cell-derived NK cell technology and engineered NK cells for improved cancer treatment.

Keywords:
NK cell therapyNK cellscancer immunotherapystem cells

More Related Videos

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.9K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.5K

Related Experiment Videos

Last Updated: Jul 26, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

888
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.9K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.5K

Area of Science:

  • Immunology
  • Cancer Biology
  • Cell Therapy

Background:

  • Natural killer (NK) cells are crucial immune sentinels capable of recognizing and eliminating transformed cells.
  • The inherent activation of NK cells makes them a promising candidate for cancer immunotherapy strategies.
  • Challenges remain in the large-scale production and therapeutic efficacy of NK cells.

Purpose of the Study:

  • To review recent advancements in stem cell-derived NK cell technology.
  • To discuss the potential of engineered NK cells for cancer immunotherapy.
  • To highlight strategies for overcoming tumor escape and enhancing NK cell potency.

Main Methods:

  • Review of current literature on stem cell-derived NK cell production.
  • Analysis of engineering strategies to enhance NK cell antitumor activity.
  • Discussion of clinical applications and challenges in NK cell therapy.

Main Results:

  • Stem cell-derived NK cell technology is rapidly advancing, offering scalable production solutions.
  • Engineered NK cells demonstrate enhanced potency and mechanisms to overcome tumor immune evasion.
  • Significant progress has been made in optimizing NK cells for therapeutic use.

Conclusions:

  • Stem cell-derived NK cells represent a viable platform for scalable cancer immunotherapy.
  • Engineered NK cells hold significant potential to improve treatment outcomes in oncology.
  • Further research and clinical translation are essential for realizing the full potential of NK cell therapy.