Renal and Electrolyte Disorders and the Nervous System

Area of Science:

• Nephrology
• Neurology
• Vascular Biology

Background:

• Neurologic complications are a major cause of death and disability in patients with renal disease.
• Renal impairment contributes to central and peripheral nervous system disorders via oxidative stress, endothelial dysfunction, and inflammation.
• The aging global population faces increasing prevalence of both renal disease and associated neurologic issues.

Conclusions:

• Renal impairment poses significant risks to both central and peripheral nervous systems.
• The kidney-brain axis is a critical area for understanding and managing neurologic complications in renal disease.
• Special considerations are needed for patients with acute kidney injury and those undergoing dialysis.