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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left Atrial Dysfunction in Apical Hypertrophic Cardiomyopathy: Assessed by Cardiovascular Magnetic Resonance

Yingxia Yang1,2, Minjie Lu3, Xuechun Guan1

  • 1Department of Radiology, The First Affiliated Hospital of Guangxi Medical University.

Journal of Thoracic Imaging
|June 21, 2023
PubMed

Insights

Apical hypertrophic cardiomyopathy (AHCM) impairs left atrial (LA) reservoir and conduit function in both typical and subclinical patients. Cardiovascular magnetic resonance feature tracking (CMR-FT) effectively quantifies these functional deficits.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Apical hypertrophic cardiomyopathy (AHCM) is a distinct form of hypertrophic cardiomyopathy.
  • Left atrial (LA) function plays a crucial role in cardiovascular health.
  • Assessing LA function in AHCM can provide insights into disease mechanisms and progression.

Purpose of the Study:

  • To evaluate left atrial (LA) function in patients with apical hypertrophic cardiomyopathy (AHCM) using cardiovascular magnetic resonance feature tracking (CMR-FT).
  • To compare LA function between typical AHCM (TAHCM), subclinical AHCM (SAHCM), and healthy controls.

Main Methods:

  • Retrospective analysis of 30 TAHCM patients, 23 SAHCM patients, and 32 healthy controls who underwent CMR.
  • Quantification of LA reservoir, conduit, and contractile function using volumetric and CMR-FT derived strain and strain rate (SR) parameters.
  • Analysis of 2-chamber and 4-chamber cine imaging.

Main Results:

  • Both TAHCM and SAHCM patients exhibited impaired LA reservoir and conduit function compared to controls.
  • LA reservoir and conduit strain were significantly associated with left ventricular mass index and maximal wall thickness.
  • While active emptying fraction and strain were preserved, TAHCM patients showed the lowest active SR.

Conclusions:

  • Left atrial (LA) reservoir and conduit functions are predominantly impaired in both subclinical and typical apical hypertrophic cardiomyopathy (AHCM) patients.
  • CMR-FT is a valuable tool for assessing LA functional deficits in AHCM.
  • These findings highlight the impact of AHCM on atrial function.
Abstract

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