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Overview of Secretory Vesicles01:33

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Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Stem Cell's Secretome Delivery Systems.

Abd Kakhar Umar1,2

  • 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Advanced Pharmaceutical Bulletin
|June 21, 2023
PubMed
Summary
This summary is machine-generated.

Stem cell secretomes offer therapeutic potential but require advanced delivery systems. Optimized dosage forms and devices enhance stability, targeted delivery, and efficacy for various organ therapies.

Keywords:
Cell-free therapySecretome delivery systemsStem cell's secretome

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Stem cell secretomes contain therapeutic biomolecules.
  • Direct administration of secretomes is limited by in vivo instability and degradation.
  • Advancements in localized and stabilized delivery systems are crucial for therapeutic efficacy.

Purpose of the Study:

  • To discuss clinical obstacles and potential solutions for secretome delivery.
  • To characterize various secretome delivery systems and associated devices.
  • To explore optimal strategies for secretome delivery in therapeutic applications.

Main Methods:

  • Review of existing literature on secretome delivery systems.
  • Analysis of physicochemical properties influencing secretome retention and release (e.g., porosity, particle size, viscoelasticity).
  • Examination of different dosage forms (hydrogels, scaffolds, coatings) and administration devices (sprayers, inhalers, implants).

Main Results:

  • Various delivery systems like hydrogels, scaffolds, and bio-mimetic coatings can stabilize and sustain secretome release.
  • Physicochemical properties of delivery systems significantly impact secretome quality, quantity, and therapeutic efficacy.
  • Specific delivery strategies are required for different organs and administration routes (e.g., lyophilized for inhalation, lipophilic for blood-brain barrier).

Conclusions:

  • Optimal secretome delivery necessitates tailored systems based on the target organ and therapeutic goal.
  • Coating, muco-adhesive, and cell-adhesive systems are vital for systemic delivery and preventing metabolism.
  • Nano-encapsulation and surface modification enhance delivery to specific organs like the liver and kidney, improving overall therapeutic outcomes.