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Published on: September 20, 2011
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Polymersomes Based Versatile Nanoplatforms for Controlled Drug Delivery and Imaging.
Rohini Kotha1, Divya Dhatri Kara1, Rajeshwari Roychowdhury2
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal-576104, India.
Advanced Pharmaceutical Bulletin
|June 21, 2023
Summary
Polymersomes, a type of nanotechnology-based drug delivery system, offer versatile applications for both hydrophilic and hydrophobic drugs. Their biocompatibility and ease of modification make them promising for targeted therapies in cancer and diabetes.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Nanotechnology-based drug delivery systems offer novel therapeutic and diagnostic potential.
- Polymersomes are advanced nano-carriers with unique properties like biocompatibility and tunable drug loading.
Purpose of the Study:
- To provide a comprehensive review of polymersomes as drug delivery systems.
- To discuss their chemical structure, formulation, characterization, and therapeutic applications.
Main Methods:
- Review of existing literature on polymersomes.
- Analysis of various formulation techniques (e.g., film rehydration, nanoprecipitation).
- Discussion of characterization methods and polymer types used.
Main Results:
- Polymersomes exhibit excellent biocompatibility, biodegradability, and stability in vivo.
- They can encapsulate both hydrophilic and hydrophobic drugs effectively.
- Surface modification allows for targeted delivery.
Conclusions:
- Polymersomes are highly versatile nano-carriers with significant potential in drug delivery.
- Their application spans diagnostics, cancer therapy, and diabetes treatment, among others.
Keywords:
Double emulsion techniqueFilm hydrationMicrofluidic techniqueNanotechnologyPolymersomesTherapeutic drug deliveryMore Related Videos
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