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Updated: Jun 24, 2026
A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
Published on: November 7, 2018
The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Shigella spp
Stuart D Blacksell1,2, Sandhya Dhawan1, Marina Kusumoto1
1Mahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Introduction:
Shigella bacteria cause shigellosis, a gastrointestinal infection most often acquired from contaminated food or water.
Methods:
In this review, the general characteristics of Shigella bacteria are described, cases of laboratory-acquired infections (LAIs) are discussed, and evidence gaps in current biosafety practices are identified.
Results:
LAIs are undoubtedly under-reported. Owing to the low infectious dose, rigorous biosafety level 2 practices are required to prevent LAIs resulting from sample manipulation or contact with infected surfaces.
Conclusions:
It is recommended that, before laboratory work with Shigella, an evidence-based risk assessment be conducted. Particular emphasis should be placed on personal protective equipment, handwashing, and containment practices for procedures that generate aerosols or droplets.
