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Related Experiment Video

Updated: Jul 26, 2025

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Hyperglycemic Hemichorea: A Case Report.

Joana Lopes1, Eulália Antunes1, Bárbara Oliveira1

  • 1Internal Medicine, Hospital de Braga, Braga, PRT.

Cureus
|June 21, 2023
PubMed
Summary

Non-ketotic hyperglycemic hemichorea-hemiballismus is a rare movement disorder linked to uncontrolled diabetes. Prompt diagnosis and metabolic control, including insulin therapy, can effectively resolve these involuntary movements.

Keywords:
decompensated diabetesdiabetes mellitus in elderlyhemiballismushemichoreahyperglycemic hemichoreainvoluntary movements

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Area of Science:

  • Neurology
  • Endocrinology
  • Radiology

Background:

  • Chorea and ballism are hyperkinetic movement disorders with diverse etiologies.
  • Non-ketotic hyperglycemic hemichorea-hemiballismus (NHH) is a rare complication of poorly controlled diabetes mellitus.
  • NHH presents with characteristic MRI findings in the basal ganglia.

Observation:

  • A 74-year-old woman with type 2 diabetes presented with acute, involuntary movements of her left side.
  • Her blood glucose was severely elevated (541 mg/dL) without ketosis, and HbA1c was 14%.
  • Brain MRI revealed T1 hyperintensity in the right corpus striatum, consistent with NHH.

Findings:

  • The patient's involuntary movements resolved after insulin therapy and haloperidol administration.
  • Metabolic optimization was key to the successful treatment of the choreiform movements.
  • The case highlights the diagnostic utility of neuroimaging in conjunction with clinical presentation.

Implications:

  • Early recognition of NHH is crucial for timely intervention and management.
  • Decompensated diabetes can manifest as a neurological emergency, necessitating prompt metabolic control.
  • Raising awareness for NHH can improve diagnosis and patient outcomes in diabetic populations.