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Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
Published on: February 22, 2017
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Legionella associated rhabdomyolysis: a case report
Helena Ma1, Avni Bavishi2, Bijal Jain3
1Northwestern University Feinberg School of Medicine, 420 E. Superior St, Chicago, IL, 60611, USA. hwma2023@gmail.com.
Journal of Medical Case Reports
|June 21, 2023
Summary
Legionella pneumophila pneumonia can cause rhabdomyolysis and acute kidney injury, a serious condition. Early recognition and treatment of Legionnaires' disease are crucial for patient recovery and preventing severe complications.
Area of Science:
- Infectious Diseases
- Nephrology
- Toxicology
Background:
- Infections are an uncommon cause of rhabdomyolysis, often associated with a poorer prognosis.
- Legionella pneumophila infections range from mild to severe, including pneumonia.
- The triad of Legionnaire's disease, rhabdomyolysis, and acute kidney injury (AKI) significantly increases morbidity and mortality.
Observation:
- A case report details a 53-year-old man with Legionella pneumophila pneumonia.
- The patient presented with rhabdomyolysis and acute kidney injury.
- The patient received aggressive fluid resuscitation and a 2-week course of azithromycin.
Findings:
- The patient's condition improved without requiring renal replacement therapy or mechanical ventilation.
- Early recognition and prompt treatment were identified as key factors in the patient's recovery.
- The patient was discharged with no recurrence of rhabdomyolysis.
Implications:
- Clinicians should consider Legionella species as a potential cause of rhabdomyolysis.
- Recognizing Legionella as an etiology is important due to its association with severe outcomes.
- Prompt diagnosis and management of Legionnaires' disease can prevent severe complications like rhabdomyolysis and AKI.
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