Related Experiment Video
Updated: Jul 26, 2025

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs
Published on: April 19, 2024
The Sweet Side of HIPK2
Alessia Garufi1, Valerio D'Orazi2, Giuseppa Pistritto3
1Unit of Cellular Networks, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Abstract:
HIPK2 is an evolutionary conserved protein kinase which modulates many molecular pathways involved in cellular functions such as apoptosis, DNA damage response, protein stability, and protein transcription. HIPK2 plays a key role in the cancer cell response to cytotoxic drugs as its deregulation impairs drug-induced cancer cell death. HIPK2 has also been involved in regulating fibrosis, angiogenesis, and neurological diseases. Recently, hyperglycemia was found to positively and/or negatively regulate HIPK2 activity, affecting not only cancer cell response to chemotherapy but also the progression of some diabetes complications. The present review will discuss how HIPK2 may be influenced by the high glucose (HG) metabolic condition and the consequences of such regulation in medical conditions.
Related Concept Videos
Hedgehog Signaling Pathway
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
PI3K/mTOR/AKT Signaling Pathway
Positive Regulator Molecules
MAPK Signaling Cascades
Regulation of Angiogenesis and Blood Supply

