MicroRNAs as powerful tool against COVID-19: Computational perspective

Area of Science:

• Biochemistry
• Genetics
• Infectious Diseases

Background:

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic.
• MicroRNAs (miRNAs) are short, noncoding RNAs involved in gene regulation and may inhibit viral replication.
• Complex metabolic pathways are regulated by interactions between proteins, mRNAs, and miRNAs.

Purpose of the Study:

• To review the role of miRNAs in combating COVID-19.
• To summarize the application of computational methods in COVID-19 research.
• To identify computational tools used against COVID-19.

Main Methods:

• Literature review focusing on microRNAs, bioinformatics, and COVID-19.
• Analysis of omics data using bioinformatics for efficient screening.
• Examination of specific studies employing computational methods.

Main Results:

• MiRNAs play a role in regulating host gene expression and viral proliferation.
• Bioinformatics enables in-depth analysis of complex metabolic networks.
• Various computational tools have been utilized in COVID-19 research.

Conclusions:

• MiRNAs are promising therapeutic targets for COVID-19.
• Bioinformatics is crucial for accelerating discoveries in infectious disease research.
• Computational approaches are vital for understanding and combating viral pandemics.