Related Experiment Video
Updated: Jul 26, 2025
10:47
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
Published on: March 2, 2018
10.0K
Neurodevelopmental disorders: 2023 update
Paulina Carriba1,2, Nicola Lorenzón1, Mara Dierssen1,3,2
1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Free Neuropathology
|June 22, 2023
Summary
Recent advances in neurodevelopmental diseases (NDDs) reveal new causes. Technologies like AI and organoids are uncovering mechanisms for conditions including autism spectrum disorder (ASD) and COVID-19 neurological effects.
Area of Science:
- Neuroscience
- Genetics
- Developmental Biology
Background:
- Neurodevelopmental diseases (NDDs) are a diverse group of disorders with varied origins.
- Technological advancements are crucial for understanding complex NDD aetiologies.
Purpose of the Study:
- To highlight recent findings and proposed aetiological mechanisms for NDDs reported in 2022.
- To showcase the impact of new technologies on NDD research.
Main Methods:
- Proteomics and RNA-sequencing for molecular profiling.
- Brain organoid models for studying neural development.
- Artificial intelligence (AI) for biodata analysis.
Main Results:
- Centrioles implicated in neuronal migration and periventricular heterotopia.
- Misfolded protein accumulation linked to COVID-19 neurological effects.
- Altered cortical arealization proposed as a mechanism for autism spectrum disorders (ASD).
Conclusions:
- New insights into NDD aetiologies are emerging due to technological progress.
- Specific findings include roles for centrioles, protein misfolding, and cortical development in NDDs.
- Future research directions include studying stress granule deregulation, novel neural progenitors, and improved diagnostics for NDDs.
Related Concept Videos
01:19Autism Spectrum Disorder
163
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
163
01:29Intellectual Disability
120
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
120
01:25Learning Disabilities
220
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
Dyslexia
Dyslexia is a...
220
01:28Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
01:30Attention-Deficit/Hyperactivity Disorder
133
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
133
01:29Three Developmental Domains
191
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and...
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and...
191