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Updated: Jul 26, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
N1-Allylation of Arylhydrazines via a Palladium-Catalyzed Allylic Substitution
Xiaojing Wang1, Xiaoshuo Wang1, Shubing Shu1
1National Engineering Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, People's Republic of China.
Abstract:
A direct and efficient method for constructing N,N-disubstituted hydrazines via a palladium-catalyzed allylic substitution of allyl acetates with arylhydrazines as nucleophiles has been developed. This method is highly selective in terms of both chemo- and regio-selectivity and is carried out under an open-air system with the use of the DPPPy phosphine ligand. Additionally, this reaction is compatible with a wide variety of substrates, including those bearing reactive groups such as Cl, Br, and I, to afford various N1-allylation products in moderate to good yields under simple and mild reaction conditions.
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