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Effects and Limitations of Naldemedine for Opioid-Induced Urinary Retention: A Case Report
Naoki Suzuki1, Megumi Okuyama1, Kohei Kamiya2
1Department of Palliative Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Abstract:
A 78-year-old man with postoperative recurrence of esophageal cancer was admitted to the hospital due to chest pain and dyspnea. Oral short-acting opioids provided some relief, but chest pain persisted and worsened, leading to the initiation of a transdermal fentanyl patch. However, the patient developed opioid-induced urinary retention, which was treated with a naldemedine, a medication used for opioid-induced constipation and urinary retention. Opioid switching led to recurrent urinary retention, requiring placement of a urinary catheter. The patient ultimately required continuous deep sedation for refractory symptoms and died several days later.
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