Related Experiment Video
Updated: Jul 26, 2025
04:23
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
399
Sarcopenia, osteoporosis and frailty
Evelien Gielen1, Jolan Dupont2, Marian Dejaeger1
1Gerontology and Geriatrics Unit, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium; Centre for Metabolic Bone Diseases, University Hospitals Leuven, Leuven, Belgium.
Metabolism: Clinical and Experimental
|June 22, 2023
Summary
Osteoporosis and sarcopenia, known as osteosarcopenia, increase fall and fracture risks. This review explores their combined impact on musculoskeletal frailty and potential treatments.
Area of Science:
- Gerontology
- Orthopedics
- Cell Biology
Background:
- Muscles and bones are interconnected tissues affected by aging and disease.
- Osteoporosis is well-defined, while sarcopenia was recently classified as a disease.
- Both conditions elevate risks of fractures, mobility issues, and mortality.
Purpose of the Study:
- To review the definitions, epidemiology, pathophysiology, and treatment of osteosarcopenia.
- To highlight osteosarcopenia as a key component of musculoskeletal frailty.
- To discuss the integrative approach to managing age-related locomotor system decline.
Main Methods:
- Narrative review of existing literature.
- Critical summary of current understanding.
- Focus on preclinical models and identified drug targets.
Main Results:
- Osteosarcopenia represents the combined effects of osteoporosis and sarcopenia.
- Muscle-bone interactions involve biomechanical, cellular, and signaling pathways.
- Preclinical studies show promise for common drug targets for simultaneous treatment.
Conclusions:
- Osteosarcopenia is a critical aspect of age-related musculoskeletal frailty.
- Understanding muscle-bone crosstalk is key to developing effective therapies.
- Further research in preclinical models may lead to novel treatments for simultaneous bone and muscle loss.
Related Concept Videos
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
01:22The Functions of the Skeletal System
4.0K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.0K
01:02What is the Skeletal System?
53.0K
Overview
53.0K
01:21Overview of Protein Metabolism
1.4K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.4K
01:26Aging
89
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
89