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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Jul 16, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
04:19

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Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction.

A M Decker1, M Matsumoto2, J T Decker3,4

  • 1Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Journal of Dental Research
|June 23, 2023
PubMed
Summary

Targeting TAM receptor tyrosine kinases, particularly Mertk, accelerates alveolar bone regeneration after tooth extraction. Inhibiting Mertk enhances bone healing and mineralization, offering new therapeutic strategies for bone repair.

Keywords:
RXDX-106inflammationosteoblastsosteogenesiswound healing

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Oral Biology

Background:

  • Alveolar bone regeneration after tooth extraction is crucial for oral function.
  • Systemic comorbidities can hinder predictable bone healing, necessitating novel therapeutic targets.
  • The TAM family (Tyro3, Axl, Mertk) of receptor tyrosine kinases are implicated in inflammation resolution and bone homeostasis.

Purpose of the Study:

  • To investigate the role of TAM receptor tyrosine kinases in alveolar bone regeneration.
  • To evaluate the therapeutic potential of TAM inhibitors in accelerating bone healing post-extraction.
  • To elucidate the specific contribution of Mertk to bone regeneration pathways.

Main Methods:

  • Utilized a mouse model of first molar extraction to assess alveolar bone fill.
  • Treated mice and human alveolar bone mesenchymal stem cells with pan-TAM and specific TAM inhibitors (RXDX-106, ASP-2215, MRX-2843).
  • Analyzed bone mineralization, immune cell infiltrate, and gene expression (RNAseq) in extraction sockets.

Main Results:

  • Pan-TAM inhibitor RXDX-106 accelerated bone fill in mice and upregulated Wnt signaling in human cells.
  • Mertk-specific inhibition and Mertk deficiency in mice enhanced alveolar bone regeneration and mineralization.
  • RNAseq revealed increased innate immune and bone differentiation pathways in Mertk-deficient mice.

Conclusions:

  • TAM receptor signaling, especially via Mertk, is a viable target for enhancing alveolar bone regeneration.
  • Targeting Mertk can accelerate bone healing and mineralization following tooth extraction.
  • These findings suggest potential therapeutic strategies for improving bone repair in challenging clinical scenarios.