Utilization of DNA and 2D metal oxide interaction for an optical biosensor

Area of Science:

• Materials Science
• Biotechnology
• Nanotechnology

Background:

• Efficient virus monitoring and early disease detection are critical.
• Biosensors are essential tools for identifying viral infections.
• Understanding DNA-surface interactions is key to biosensor development.

Purpose of the Study:

• To investigate the interaction between DNA and 2D metal oxides for biosensor applications.
• To develop novel biosensors for the early detection of viral infections.
• To provide a microscopic understanding of DNA-metal oxide interactions.

Main Methods:

• Spectroscopic measurements to probe DNA-metal oxide interactions.
• Fully atomistic molecular dynamics (MD) simulations for microscopic analysis.
• In silico assessment of DNA conformational changes during adsorption.

Main Results:

• Demonstrated efficient interactions between single-stranded DNA (ssDNA) and 2D metal oxides.
• Identified 5'-guanine as the primary interacting nucleotide base.
• Quantified conformational changes of ssDNA upon adsorption on the metal oxide surface.

Conclusions:

• DNA-metal oxide interactions are suitable for developing effective viral infection biosensors.
• The study provides a microscopic understanding of ssDNA adsorption mechanisms.
• These findings can guide the design of advanced systems for pandemic prevention.