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Neutrophilic eccrine hidradenitis: a retrospective study
Nasro A Isaq1, Nimay Anand2,3, Michael J Camilleri4,5
1Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
International Journal of Dermatology
|June 23, 2023
Summary
Neutrophilic eccrine hidradenitis (NEH) in adults often links to malignancy and chemotherapy. In children, NEH typically follows overexertion and is rarely associated with cancer.
Area of Science:
- Dermatology
- Oncology
- Pediatrics
Background:
- Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis.
- While often associated with malignancy in adults, this link is uncommon in children.
- Diagnosis in adults typically requires histology, unlike in children.
Purpose of the Study:
- To investigate risk factors, clinical features, treatments, and outcomes of NEH.
- To differentiate NEH characteristics between adult and pediatric populations.
- To clarify the association of NEH with malignancy and other triggers.
Main Methods:
- Retrospective study of adult and pediatric NEH patients (1992-2022).
- Data collected from health records, including clinical information and pathology.
- Pathology slides reviewed by a dermatopathologist.
Main Results:
- 33 patients confirmed NEH; 21 adults (64%) and 12 children (36%).
- Adult NEH frequently linked to malignancy (76%) and chemotherapy.
- Pediatric NEH rarely associated with malignancy (8%); often preceded by strenuous activity (83%).
- Idiopathic NEH presented with palmoplantar lesions in both groups.
- Malignancy-associated NEH commonly affected the face and axillae.
Conclusions:
- Adult NEH is strongly associated with malignancy and chemotherapy.
- Pediatric NEH is primarily idiopathic, often triggered by overexertion.
- Malignancy is an unlikely cause of NEH in children.
