The association between aldehydes exposure and female infertility: A cross-sectional study from NHANES

Environmental pollutants could be implicated in the cause of female infertility beyond traditional factors. Until now, no study has focused on the association of environmental exposure to aldehydes with female infertility. This study intended to investigate the possible impact of serum levels of aldehyde on female infertility. A cross-sectional study was performed on 516 nationally representative participants from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES) in US. Multivariate logistic regression models and restricted cubic splines were used to examine the association between serum levels of aldehydes and the risk of female infertility. Women in the highest tertile of exposure to benzaldehyde had a 66% (odds ratio [OR] = 0.34, 95% confidence interval [CI] = 0.14-0.79) lower risk of infertility compared to those in the lowest tertile, after adjusting for other variables. Restricted cubic spline indicated a linear and negative association of benzaldehyde with female infertility (p for nonlinearity = 0.74), while other aldehydes did not exhibit a significant correlation. In summary, this cross-sectional study indicates that higher benzaldehyde level correlated with a lower rate of female infertility, which could help guide future research and contribute to the development of interventions to prevent or treat infertility and improve reproductive health outcomes.