Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

46
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
46
Antibiotic Selection00:57

Antibiotic Selection

54.8K
Overview
54.8K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

49
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
49
Antimicrobial Proteins01:23

Antimicrobial Proteins

1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current State and Needs of Clinical Laboratories in Selected Countries in Africa.

The journal of applied laboratory medicine·2026
Same author

Creation and evaluation of a combined pathology resident rotation in immunology, histocompatibility, and coagulation.

American journal of clinical pathology·2025
Same author

Reply to "Escalation process of critical values when these cannot be communicated on first attempt: a hospital-wide process improvement project".

American journal of clinical pathology·2025
Same author

Therapeutic plasma exchange for fibrinogen-associated hyperviscosity: results of the COVID-19 PLasma EXchange (COPLEX) randomized controlled trial.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Enhancing Apheresis Knowledge: An Educational Intervention for Non-Apheresis Medical Providers.

Journal of clinical apheresis·2024
Same author

Escalation process of critical values when these cannot be communicated on first attempt: A hospital-wide process improvement project.

American journal of clinical pathology·2024

Related Experiment Video

Updated: Jul 25, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K

Emerging Antimicrobial Resistance.

Cynthia E Flynn1, Jeannette Guarner2

  • 1Department of Pathology, Christiana Care, Wilmington, Delaware.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|June 23, 2023
PubMed
Summary
This summary is machine-generated.

Antimicrobial resistance (AMR) causes millions of infections and thousands of deaths annually in the US. This review details urgent threats, resistance mechanisms, diagnostics, and therapies to combat AMR.

Keywords:
Pseudomonas aeruginosaStreptococcus pneumoniaantibiotic resistancecarbapenem-resistant Acinetobacter baumanniidrug-resistant Mycobacterium tuberculosisextended spectrum beta-lactamasemethicillin-resistant Staphylococcus aureus

More Related Videos

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

11.8K
Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.1K

Related Experiment Videos

Last Updated: Jul 25, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

6.6K
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
09:00

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

Published on: May 2, 2018

11.8K
Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.1K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat, with millions of infections and tens of thousands of deaths annually in the United States.
  • Despite mitigation efforts, AMR remains a critical challenge, necessitating comprehensive strategies for control and prevention.

Purpose of the Study:

  • To review the Centers for Disease Control and Prevention's (CDC) categorized list of antibiotic-resistant threats.
  • To detail the epidemiology, resistance mechanisms, diagnostics, and therapeutic strategies for key AMR pathogens.
  • To present pathological findings of partially treated bacteria in tissues.

Main Methods:

  • Review of the 2019 CDC report on antibiotic-resistant threats.
  • Analysis of epidemiological data, resistance mechanisms, diagnostic limitations, and current/future therapies for categorized bacteria.
  • Inclusion of anatomical pathology case examples illustrating morphological changes in antibiotic-treated bacteria.

Main Results:

  • The CDC categorizes AMR threats into urgent, serious, and concerning groups.
  • Specific details on cases, deaths, resistance mechanisms, diagnostics, and therapies are provided for each bacterium.
  • Pathology examples highlight morphological alterations in bacteria under partial antibiotic treatment.

Conclusions:

  • A multi-faceted approach including infection control, stewardship, and novel therapies is crucial to mitigate AMR.
  • Understanding resistance mechanisms and improving diagnostics are key to effective treatment.
  • Continued surveillance and research are vital to combat the evolving threat of antimicrobial resistance.