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ELAC2 is a functional prostate cancer risk allele
Steven Blinka1, Rashmi Mishra2, Andrew C Hsieh1
1Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; School of Medicine, University of Washington, Seattle, WA 98195, USA.
Trends in Molecular Medicine
|June 23, 2023
Abstract
None:
Stentenbach and colleagues have unveiled a functional role of a human germline mutation found in the ribonuclease (RNase) Z enzyme, ELAC2, in prostate cancer. Here, we discuss the importance of these findings in enhancing our understanding of how risk variants enable prostate cancer progression and the post-transcriptional mechanisms underlying oncogenesis.

