Related Experiment Video

Updated: Jul 25, 2025

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

727

Left atrioventricular coupling index assessed using cardiac CT as a prognostic marker of cardiovascular death

Théo Pezel1, Jean-Guillaume Dillinger2, Solenn Toupin3

  • 1Université Paris Cité, Department of Cardiology, Hôpital Lariboisière - APHP, Inserm UMRS 942, 75010, Paris, France; Université Paris Cité, Department of Radiology, Hôpital Lariboisière - APHP, 75010, Paris, France.

Diagnostic and Interventional Imaging
|June 23, 2023
PubMed

Insights

The left atrioventricular coupling index (LACI) measured by cardiac CT effectively predicts cardiovascular death in patients without known heart disease. This index offers significant prognostic value beyond traditional risk factors and CT findings.

Area of Science:

  • Cardiology
  • Radiology
  • Biomedical Engineering

Background:

  • Cardiovascular disease remains a leading cause of mortality worldwide.
  • Accurate risk stratification is crucial for early intervention and improved patient outcomes.
  • Cardiac computed tomography (CT) offers detailed anatomical and functional information.

Purpose of the Study:

  • To evaluate the prognostic capability of the left atrioventricular coupling index (LACI) using cardiac CT.
  • To determine if LACI can predict cardiovascular death in patients undergoing cardiac CT for coronary analysis.
  • To assess the incremental value of LACI over established risk factors and CT findings.

Main Methods:

  • A single-center study included 1,444 consecutive patients without known cardiovascular disease referred for cardiac CT between 2010 and 2020.
  • LACI was calculated as the ratio of left atrial to left ventricle end-diastolic volumes.
  • Cox regression models were employed to analyze the association between LACI and cardiovascular death, adjusting for confounders.

Main Results:

  • A total of 67 patients (4.3%) experienced cardiovascular death during a median follow-up of 6.8 years.
  • Adjusted analyses revealed a significant positive association between LACI and both cardiovascular death (aHR 1.07 per 1% increment) and all-cause death (aHR 1.05 per 1% increment).
  • A LACI threshold of ≥ 25% demonstrated superior model discrimination and reclassification for predicting cardiovascular death.

Conclusions:

  • The left atrioventricular coupling index (LACI), derived from cardiac CT, is an independent predictor of cardiovascular and all-cause mortality.
  • LACI provides significant prognostic information that complements traditional risk factors and cardiac CT angiography findings.
  • Cardiac CT-derived LACI can enhance risk stratification in patients without known cardiovascular disease.
Abstract

Keywords:
All-cause deathCardiac computed tomography angiographyCardiovascular deathLeft atrioventricular coupling index

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.6K

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
45
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
42
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
11
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
33
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
24
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
65