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Updated: Jul 25, 2025

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis

Published on: May 16, 2025

Dissecting mammalian reproduction with spatial transcriptomics.

Xin Zhang^1,2, Qiqi Cao^1,2, Shreya Rajachandran^1,2

¹Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Human Reproduction Update

|June 24, 2023

Summary

This summary is machine-generated.

Spatial omics technologies reveal novel biological insights into mammalian reproduction by preserving cellular context. This review updates reproductive biologists and clinicians on spatial transcriptomics (ST) applications and future directions.

Keywords:

cancer embryogenesis gametogenesis pregnancy reproduction spatial transcriptomics

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Area of Science:

Reproductive biology and medicine
Genomics and molecular biology
Biotechnology

Background:

Mammalian reproduction relies on gamete fusion and embryonic development within a specialized environment.
Understanding reproductive systems requires knowledge of cell types, cell-cell interactions, and gene regulation.
Single-cell omics provide cellular insights but lack spatial context, limiting understanding of tissue interactions.

Approach:

This review critically evaluates peer-reviewed articles and reviews on spatial omics and transcriptomics in reproduction.
PubMed searches utilized keywords like 'spatial omics,' 'fertility,' 'gametogenesis,' and 'embryogenesis' up to April 2023.
The review provides an overview of spatial transcriptomics technologies, their advantages, and limitations.

Key Points:

Spatial transcriptomics (ST) reveals novel biological insights into gametogenesis, embryogenesis, and reproductive pathologies.
ST identifies genes with non-random spatial expression, spatially clustered interacting cell types, and unique cellular microenvironments in pathologies.
Challenges in applying ST to reproduction include experimental and computational hurdles, with potential solutions and future directions discussed.

Conclusions:

Spatial omics technologies offer significant potential for novel insights into mammalian reproduction, complementing single-cell approaches.
This review updates reproductive biologists and clinicians on the state-of-the-art in ST for reproductive research.
Adoption of cutting-edge spatial technologies can advance both basic and clinical reproductive research.