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Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

Xi Dawn Chen1,2,3, Zeyu Chen1,4,5, George Wythes1

  • 1Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|October 10, 2024
PubMed
Summary

A new tool called helicase-assisted continuous editing (HACE) enables targeted, long-range DNA mutations. This platform helps researchers understand gene function and discover new biological capabilities.

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