Connecting the Dots: N6-Methyladenosine (m⁶ A) Modification in Spermatogenesis

N6-methyladenosine (m⁶ A) is the most common RNA modification found in eukaryotes and is involved in multiple biological processes, including neuronal development, tumorigenesis, and gametogenesis. It is well known that methylation-modifying enzymes (classified into writers, erasers, and readers) mediate catalysis, clearance, and recognition of m⁶ A. Recent studies suggest that these genes may be associated with spermatogenesis. Numerous studies have revealed the m⁶ A role during spermatogenesis. However, the expression patterns and relationships of these m⁶ A enzymes during various stages of spermatogenesis remain unknown. In this review, it is aimed to provide an overview of m⁶ A enzyme functions and elucidate their potential mechanisms and regulatory relationships at a specific phase during spermatogenesis, providing new insights into the m⁶ A modification underlying the spermatogenesis process.