A COMPARATIVE REVIEW OF THE USE OF DANIO RERIO (ZEBRAFISH) AS A MODEL OBJECT IN PRECLINICAL STUDIES

Danio rerio (Zebrafish) as a model object in preclinical studies have been widely used in recent years. This is facilitated by their morphological, physiological, biochemical, genetic, and embryological characteristics, as well as economic benefits and small-time costs of their breeding. The aim is to summarize the available data on the use of Danio rerio (Zebrafish) in preclinical studies. In this work a review of domestic and foreign articles on the use of Danio rerio in toxicological, pharmacological, embryological, and other research areas was carried out. Danio rerio (Zebrafish) can be used in many areas of preclinical studies of drugs. Their application in modeling novelty stress and experimental depression is especially interesting. Danio rerio are a versatile model object that allows cost-effective studies of various pharmacological drugs before they are tested on other models, particularly mammals.