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Highly efficient photocathodic cascade material for constructing sensitive photoelectrochemical biosensor.
Mingjun Xiao1, Qian Xiong1, Chaoju Yang2
1Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China.
Analytica Chimica Acta
|June 24, 2023
Summary
This study introduces a novel P3HT@C60@ZnO nanosphere for photocathodic biosensors, significantly boosting photocurrent by 30 times. This advancement enables highly sensitive detection of p53, crucial for early disease diagnosis.
Area of Science:
- Materials Science
- Nanotechnology
- Biosensing
Background:
- Photocathodic biosensors offer excellent anti-interference but suffer from low photocurrent due to high electron-hole recombination.
- Developing efficient photoactive probes is crucial for enhancing biosensor performance.
Purpose of the Study:
- To synthesize a high-performance inorganic-organic P3HT@C60@ZnO nanosphere as a photoactive signal probe.
- To develop a sensitive photocathodic biosensor for p53 detection using the novel nanosphere and DNA nanonet amplification.
- To improve photoelectric conversion efficiency and photocathodic signal in biosensing applications.
Main Methods:
- Synthesis of P3HT@C60@ZnO nanosphere with a cascade energy band arrangement.
- Integration of the nanosphere with a DNA nanonet amplified via clamped hybrid chain reaction (C-HCR).
- Fabrication and testing of the P3HT@C60@ZnO nanosphere-based photocathodic biosensor for p53 detection.
Main Results:
- The P3HT@C60@ZnO nanosphere exhibited enhanced light absorption and charge carrier separation, leading to a 30-fold increase in photocathodic signal.
- The developed biosensor demonstrated a wide detection range (0.1 fM to 10 nM) and a low detection limit (0.37 fM) for p53.
- The cascade energy band arrangement improved carrier lifetime and charge separation, enhancing photoelectric conversion efficiency.
Conclusions:
- The P3HT@C60@ZnO nanosphere is a highly effective photoactive probe for photocathodic biosensors.
- The developed biosensor offers superior sensitivity and anti-interference capabilities for p53 detection.
- This work presents a promising platform for sensitive photoelectrochemical (PEC) sensing and early disease diagnosis.
