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Does corneal epithelial thickness show the severity of psoriasis? SD-OCT study
İrfan Botan Güneş1, Berna Aksoy2, Hakan Öztürk3
1Department of Ophthalmology, Kocaeli Health and Technology University, Medical Park Kocaeli Hospital, Kocaeli, Turkey.
Anais Brasileiros De Dermatologia
|June 24, 2023
Summary
Psoriasis severity correlates with central corneal epithelial thickness (CCET). Increased CCET, measured by spectral domain-optical coherence tomography (SD-OCT), may indicate greater psoriasis severity.
Area of Science:
- Ophthalmology
- Dermatology
- Medical Imaging
Background:
- Psoriasis research often focuses on ocular conditions like uveitis and blepharitis.
- The Psoriasis Area and Severity Index (PASI) is complex for assessing disease severity.
Purpose of the Study:
- To investigate the correlation between psoriasis severity and central corneal epithelial thickness (CCET).
Main Methods:
- Compared CCET in 175 psoriasis patients (mild, moderate, severe based on PASI score) and 57 controls.
- Utilized spectral domain-optical coherence tomography (SD-OCT) for CCET measurements.
- Analyzed the relationship between PASI scores and CCET values.
Main Results:
- Mean CCET was significantly higher in all psoriasis groups versus controls.
- CCET increased progressively with psoriasis severity (mild < moderate < severe).
- A strong positive correlation (r=0.519) was found between PASI score and CCET.
Conclusions:
- Psoriasis severity shows a strong positive correlation with CCET.
- SD-OCT measurement of CCET offers a potential indicator for assessing psoriasis severity.
