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Updated: Jul 25, 2025

Analysis of Cap-binding Proteins in Human Cells Exposed to Physiological Oxygen Conditions
Published on: December 28, 2016
DXO gears mRNA with alternative NAD and m7G caps
1Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China.
Abstract:
NAD is a noncanonical mRNA cap that challenges our traditional dogma of N7-methylguanosine (m7G)-capped eukaryotic mRNAs. The relationship between NAD and m7G caps has been elusive. Xiao et al. find that the deNADding enzyme DXO promotes maturation of m7G caps, suggesting that DXO fine-tunes the dynamic balance between alternative RNA cap structures.
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