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The prognostic impact of specialist cardiology input in patients admitted for heart failure and normal ejection
Antonio Cannata1,2, Layla Badawy1, Anawinla Ta Anyu1
1Department of Cardiology, King's College Hospital London, London, UK.
Insights
Specialist cardiology care for heart failure with normal ejection fraction (HFnEF) does not improve long-term survival. However, it is linked to a significant reduction in deaths during hospitalization for these patients.
Area of Science:
- Cardiology
- Heart Failure Research
- Clinical Outcomes
Background:
- Specialist cardiology care improves outcomes for heart failure with reduced ejection fraction (HFrEF).
- However, the impact of specialist input on patients with heart failure with normal ejection fraction (HFnEF) is not well understood.
- A significant proportion of HFnEF patients do not receive cardiology consultation during hospitalization.
Purpose of the Study:
- To investigate the prognostic implications of specialist cardiology input in patients hospitalized with HFnEF.
- To determine if cardiology consultation affects in-hospital and long-term mortality in HFnEF patients.
Main Methods:
- Retrospective analysis of 1413 hospitalized HFnEF patients from two tertiary centers.
- Primary outcome: all-cause mortality during follow-up. Secondary outcome: in-hospital mortality.
- Comparison of characteristics and outcomes between patients who received and did not receive specialist cardiology input.
Main Results:
- 23% of HFnEF patients did not receive specialist cardiology input.
- Patients seen by cardiologists had fewer comorbidities but more severe clinical presentations.
- No significant difference in long-term mortality; however, specialist input was associated with lower in-hospital mortality (HR 0.19).
Conclusions:
- In-hospital specialist cardiology input does not confer a long-term prognostic advantage for HFnEF patients.
- However, cardiology consultation is independently associated with a significant reduction in in-hospital mortality for this patient group.
Aims:
Specialist cardiology care is associated with a prognostic benefit in patients with heart failure (HF) with reduced ejection fraction (HFrEF) admitted with decompensated HF. However, up to one third of patients admitted with HF and normal ejection fraction (HFnEF) do not receive specialist cardiology input. Whether this has prognostic implications is unknown.
Methods And Results:
Data on patients hospitalized with HFnEF from two tertiary centres were analysed. The primary outcome measure was all-cause mortality during follow-up. The secondary outcome was in-hospital mortality. A total of 1413 patients were included in the study. Of these, 23% (n = 322) did not receive in-hospital specialist cardiology input. Patients seen by a cardiologist were less likely to have hypertension (73% vs. 79%, P = 0.03) and respiratory co-morbidities (25% vs. 31%, P = 0.02) compared with those who did not receive specialist input. Similarly, clinical presentation was more severe for those who received specialist input (New York Heart Association III/IV 83% vs. 75% respectively, P = 0.003; moderate-to-severe peripheral oedema 65% vs. 54%, P < 0.001). Medical management was similar, except for a higher use of diuretics (90% vs. 86%, P = 0.04) and a longer length of stay for patients who received specialist input (9 vs. 4 days, P < 0.001). Long-term outcomes were comparable between patients who received specialist input and those who did not. However, specialist input was independently associated with lower in-hospital mortality (hazard ratio 0.19, confidence interval 0.09-0.43, P < 0.001).
Conclusions:
In-hospital cardiology specialist input has no long-term prognostic advantage in patients with HFnEF but is independently associated with reduced in-hospital mortality.
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