Related Experiment Video
Updated: Jul 25, 2025
07:12
Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
7.9K
Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes
Swati Bugalia1, Yogpal Dhayal2, Harshita Sachdeva1
1Department of Chemistry, University of Rajasthan, Jaipur, 302004 India.
Journal of Inorganic and Organometallic Polymers and Materials
|June 26, 2023
Summary
Synthetic coordination chemistry utilizes isatin-based macrocyclic complexes for drug discovery. These transition metal complexes show broad pharmaceutical applications, including antimicrobial, anticancer, and anti-inflammatory activities, highlighting their therapeutic potential.
Area of Science:
- Coordination Chemistry
- Medicinal Chemistry
- Pharmaceutical Science
Background:
- Isatin (1H-Indole-2,3-dione) is a versatile compound found in nature and synthesized for drug design.
- Isatin derivatives serve as precursors for macrocyclic ligands in coordination chemistry.
- Transition metal complexes with isatin-based ligands exhibit diverse biological activities.
Purpose of the Study:
- To review the synthesis and characterization of macrocyclic complexes of transition metal ions using isatin and its derivatives.
- To explore the extensive pharmaceutical applications of these synthesized complexes in medicinal chemistry.
Main Methods:
- Synthesis of macrocyclic complexes incorporating isatin or its derivatives as ligands.
- Characterization of the synthesized transition metal complexes.
- Evaluation of the biological and pharmacological activities of the complexes.
Main Results:
- Isatin-based macrocyclic complexes of transition metals have been successfully synthesized.
- These complexes demonstrate a wide spectrum of pharmacological activities, including antimicrobial, anticancer, antiviral, and anti-inflammatory properties.
- The review compiles the latest synthetic methodologies and application data.
Conclusions:
- Synthetic coordination chemistry offers significant potential in pharmaceutical science through isatin-based macrocyclic complexes.
- These complexes represent promising candidates for the development of novel therapeutic agents.
- Further research into isatin derivatives and their metal complexes can lead to new drug discoveries.
Related Concept Videos
02:52Stereoisomerism
12.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.2K
02:34Structural Isomerism
19.5K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.5K
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
416
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
416
01:28Structure-Activity Relationships and Drug Design
794
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
794