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Related Experiment Video

Updated: Jul 25, 2025

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Human disease models in drug development.

Anna Loewa¹, James J Feng^2,3, Sarah Hedtrich^1,4,5,6

¹Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.

Nature Reviews Bioengineering

|June 26, 2023

Summary

This summary is machine-generated.

Biomedical research is shifting to human disease models due to animal model limitations. Bioengineered models like organoids and organs-on-chips offer better clinical mimicry to improve drug development.

Keywords:

Molecular medicine Translational research

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Area of Science:

Biomedical research
Translational science
Drug discovery

Background:

Current drug development faces high failure rates.
Traditional animal models exhibit significant interspecies differences and poor predictive value for human conditions.
A paradigm shift towards human-centric disease models is underway.

Purpose of the Study:

To review the application of bioengineered human disease models in preclinical and clinical studies.
To highlight the benefits of organoids, bioengineered tissue models, and organs-on-chips.
To propose a framework for accelerating clinical translation and drug development.

Main Methods:

Review of preclinical and clinical studies utilizing bioengineered human disease models.
Focus on organoids, bioengineered tissue models, and organs-on-chips.
Development of a high-level design framework for clinical translation.

Main Results:

Bioengineered human disease models demonstrate high clinical mimicry.
These models have shown benefits in various preclinical and clinical studies.
A framework is proposed to guide the use of these models.

Conclusions:

Bioengineered human disease models are crucial for bridging the translational gap in drug development.
Organoids, tissue models, and organs-on-chips represent key advancements.
Implementing a structured design framework can accelerate the development of effective therapeutics.