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A Human-based Skin-lymphoreticular Model-on-chip To Emulate Inflammatory Skin Conditions.

Home
A Human-based Skin-lymphoreticular Model-on-chip To Emulate Inflammatory Skin Conditions.

Related Experiment Video

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

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Published on: May 28, 2021

A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions.

Zheng Tan¹, Partho Protim Adhikary¹, Dana Wörz²

¹Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.

Advanced Healthcare Materials

|January 7, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Researchers developed a human-based skin-lymphoreticular model to study immune responses. This bioengineered system mimics interactions between skin and draining lymph nodes, aiding in understanding inflammatory conditions.

Keywords:

atopic diseases bioengineered lymph nodes human‐based models lymphoreticular tissue model organ‐on‐chip secondary lymphoid tissue skin sensitization

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Published on: May 17, 2021

Area of Science:

Bioengineering
Immunology
Tissue Engineering

Background:

Human-based bioengineered models struggle to replicate complex immunoregulations.
Existing models often lack secondary lymphoid tissues crucial for immune responses.

Purpose of the Study:

To create a self-assembled, functional lymphoreticular unit that models human lymphoid tissue.
To establish a co-culture system for studying skin-lymph node interactions under inflammation.

Main Methods:

Layer-by-layer assembly of fibroblastic reticular cells, lymphatic endothelial cells, and CD4+ T cells.
Development of a microfluidic organ-on-chip platform for skin-lymphoreticular co-culture.
Verification of T cell migration and response to inflammatory stimuli and anti-inflammatory drugs.

Main Results:

A self-organized, compartmentalized lymphoreticular model was successfully created.
The model demonstrated T cell migration and infiltration in response to atopic-like skin models and sensitizers.
Anti-inflammatory drugs effectively abrogated T cell-mediated effects, confirming model functionality.

Conclusions:

The developed human-based skin-lymphoreticular model represents a minimally functional unit for studying skin-lymphoid interactions.
This model provides a novel platform for investigating immune responses in a human-relevant context.
The system allows for the assessment of therapeutic interventions targeting skin-associated inflammation.