Related Experiment Video
Updated: Jul 25, 2025

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis
Published on: March 9, 2022
A computational technique for the Caputo fractal-fractional diabetes mellitus model without genetic factors
Berat Karaagac1, Kolade M Owolabi2, Edson Pindza3
1Faculty of Education, Department of Mathematics Education, Adiyaman University, Adiyaman, Turkey.
Abstract:
The concept of a Caputo fractal-fractional derivative is a new class of non-integer order derivative with a power-law kernel that has many applications in real-life scenarios. This new derivative is applied newly to model the dynamics of diabetes mellitus disease because the operator can be applied to formulate some models which describe the dynamics with memory effects. Diabetes mellitus as one of the leading diseases of our century is a type of disease that is widely observed worldwide and takes the first place in the evolution of many fatal diseases. Diabetes is tagged as a chronic, metabolic disease signalized by elevated levels of blood glucose (or blood sugar), which results over time in serious damage to the heart, blood vessels, eyes, kidneys, and nerves in the body. The present study is devoted to mathematical modeling and analysis of the diabetes mellitus model without genetic factors in the sense of fractional-fractal derivative. At first, the critical points of the diabetes mellitus model are investigated; then Picard's theorem idea is applied to investigate the existence and uniqueness of the solutions of the model under the fractional-fractal operator. The resulting discretized system of fractal-fractional differential equations is integrated in time with the MATLAB inbuilt Ode45 and Ode15s packages. A step-by-step and easy-to-adapt MATLAB algorithm is also provided for scholars to reproduce. Simulation experiments that revealed the dynamic behavior of the model for different instances of fractal-fractional parameters in the sense of the Caputo operator are displayed in the table and figures. It was observed in the numerical experiments that a decrease in both fractal dimensions and leads to an increase in the number of people living with diabetes mellitus.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Mechanistic Models: Compartment Models in Individual and Population Analysis
Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs
On the other hand, integral calculus focuses on...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

