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Updated: Jul 25, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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BRCA2 reversion mutation confers resistance to olaparib in breast cancer

Shinya Yamamoto1, Kei Kawashima1, Yoshie Fujiwara1

  • 1Department of Breast and Thyroid Surgery Yokohama City University Medical Center Yokohama Japan.

Clinical Case Reports
|June 26, 2023
PubMed

Insights

A rare reversion mutation in BRCA2, p.Gln3047Tyr, was identified as a mechanism of resistance to olaparib in a breast cancer patient. This finding is crucial for understanding treatment resistance in BRCA-mutated cancers.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Olaparib is a PARP inhibitor used to treat BRCA-mutated breast cancer.
  • Resistance to olaparib can develop through various mechanisms, including secondary mutations in BRCA genes.
Keywords:
BRCAbreast neoplasmsgenomicsolaparib

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