Related Experiment Video
Updated: Jul 25, 2025
07:20
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
14.0K
Synthesis, structural characterization, thermal analysis, DFT, biocidal evaluation and molecular docking studies of
Subhash1, Ashu Chaudhary1, Mamta1
1Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana 136119 India.
Chemicke Zvesti
|June 26, 2023
Summary
New cobalt (II) complexes derived from tetraamide macrocyclic ligands exhibit significant antimicrobial and antioxidant activities. Ligand TAML1 and its cobalt complex show excellent antibacterial properties against Staphylococcus aureus.
Area of Science:
- Coordination Chemistry
- Medicinal Chemistry
- Materials Science
Background:
- Transition metal complexes, particularly those derived from amino acids and aromatic amines, are recognized for their physiological activity.
- Cobalt (II) complexes are of interest due to their diverse applications.
Purpose of the Study:
- To synthesize and characterize novel Cobalt (II) complexes using 1,8-diaminonaphthalene-based tetraamide macrocyclic ligands.
- To evaluate the antimicrobial, antioxidant, and biological significance of these synthesized ligands and their Co(II) complexes.
Main Methods:
- Synthesis of Cobalt (II) complexes with tetraamide macrocyclic ligands (TAML1-3) in ethanolic media.
- Characterization using spectroscopic techniques (IR, NMR, EPR, UV-Vis), CHN analysis, TGA, X-ray diffraction, and DFT analysis.
- Antimicrobial activity testing against various bacteria and fungi, antioxidant assays, and molecular docking studies.
Main Results:
- Successful synthesis and full characterization of TAML1-3 ligands and their Co(II) complexes, confirming distorted octahedral geometry.
- Ligand TAML1 and its cobalt complex [Co(TAML1)Cl2] demonstrated potent antibacterial activity against Staphylococcus aureus, surpassing ampicillin.
- All synthesized compounds exhibited notable antioxidant activity, and molecular docking results correlated well with experimental antimicrobial data.
Conclusions:
- The synthesized Cobalt (II) macrocyclic complexes possess significant antimicrobial and antioxidant properties.
- The study highlights the potential of these novel complexes as therapeutic agents, particularly for bacterial infections.
- Molecular docking provides valuable insights into the mechanism of action and potential drug targets.
Related Concept Videos
01:29Preparation of Amides
3.2K
Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
3.2K
02:34Structural Isomerism
19.5K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.5K
02:54Coordination Compounds and Nomenclature
21.7K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
21.7K
02:52Stereoisomerism
12.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.2K
01:28Structures of Carboxylic Acid Derivatives
2.7K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the...
2.7K
02:58Crystal Field Theory - Octahedral Complexes
26.9K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
26.9K