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DNA Vector-based RNA Interference to Study Gene Function in Cancer
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The Role of DNA Viruses in Human Cancer

Zohreh-Al-Sadat Ghoreshi1, Hamid Reza Molaei2, Nasir Arefinia1

  • 1Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran.

Cancer Informatics
|June 26, 2023
PubMed

Insights

Virus infections cause 15-20% of human cancers by manipulating cellular pathways. Viral oncoproteins interact with deubiquitinases (DUBs), impacting cell stability and promoting cancer development, including HPV-linked and Hepatitis B-associated malignancies.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Infections are linked to a significant portion of human cancers.
  • Viral infections contribute 15-20% of all cancer cases globally.
  • DNA viruses encode proteins that interfere with host cellular signaling.

Purpose of the Study:

  • To review the role of virus infections in human cancers.
  • To explore the mechanisms by which viral oncoproteins contribute to cancer development.
  • To highlight specific viruses and their associated malignancies.

Main Methods:

  • Literature review of studies on virus-associated cancers.
  • Analysis of molecular interactions between viral oncoproteins and host cellular machinery.
  • Compilation of data on prevalence and types of virus-linked cancers.

Main Results:

  • Viral oncoproteins interact with host Deubiquitinases (DUBs) to enhance stability and signaling.
  • This interaction promotes uncontrolled cell proliferation, inhibits cell death, and disrupts genomic integrity.
  • Specific examples include Human Papillomaviruses (cervical, oral cancers), Hepatitis B (HCC), and Epstein-Barr virus (lymphomas, nasopharyngeal carcinoma).

Conclusions:

  • Virus infections are a major etiological factor in a substantial percentage of human cancers.
  • Understanding viral oncoprotein interactions with DUBs is crucial for developing targeted cancer therapies.
  • Targeting these viral-host interactions could offer new strategies for cancer prevention and treatment.
Keywords:
DNA virusescanceroncogenic viruses

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