You might also read
Articles linked to this work by shared authors, journal, and citation graph.
Updated: Jul 25, 2025
Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Sagar Pokhrel1, Amrit Bhusal1, Neelam Kumari1
1Department of Pediatrics and Adolescents Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.
This case report describes an 8-year-old boy who developed cholestasis due to Hepatitis E virus (HEV) infection. HEV is typically mild in children and often goes undiagnosed. However, this child presented with fever and signs of acute cholestasis. Tests confirmed HEV infection and liver damage. The child was treated symptomatically and recovered. The authors suggest that cholestasis, though rare, should be considered in children with unexplained liver issues. This is the first reported case from Nepal of HEV-induced cholestasis in a child.
Area of Science:
Background:
Hepatitis E virus (HEV) is a significant cause of waterborne hepatitis in tropical and subtropical regions. Infections in children are often asymptomatic or mild, with few cases progressing to jaundice. Prior research has shown that HEV typically does not lead to severe liver complications in pediatric patients. This gap motivated the documentation of a rare case involving cholestasis in a child. No prior work had resolved the frequency of cholestasis in HEV-infected children. The lack of awareness about this complication may lead to misdiagnosis or delayed treatment. Understanding the full spectrum of HEV in children is essential for clinical management. This case highlights the need for broader recognition of HEV-related liver complications.
Purpose Of The Study:
The aim of this case report is to document an unusual presentation of HEV infection in a child. The specific problem is the occurrence of cholestasis, a rare complication in pediatric HEV cases. The motivation is to raise awareness among clinicians about this possibility. The authors propose that HEV should be considered in children presenting with unexplained cholestasis. This report may help improve diagnostic approaches in similar cases. The study does not aim to generalize findings but to describe a unique observation. The authors emphasize the importance of follow-up in HEV-infected patients with jaundice. This case may prompt further investigation into HEV-related liver complications.
Main Methods:
The study involved a case report of an 8-year-old male child presenting with fever and acute cholestasis. Clinical assessment included physical examination and systemic evaluations. Diagnostic tools included ultrasonography and liver biopsy. Serological testing for HEV IgM was conducted. The child was managed symptomatically without antiviral therapy. No experimental interventions were performed. The report relies on clinical observations and standard diagnostic procedures. The authors did not conduct follow-up studies beyond the initial clinical course.
Main Results:
The child presented with fever and acute cholestasis. Ultrasonography suggested acute hepatitis. Liver biopsy confirmed hepatic cholestasis and hepatitis. Serological testing showed a positive result for HEV IgM. The child was managed symptomatically. No antiviral treatment was administered. The clinical course resolved without complications. The authors propose that cholestasis is a rare but possible complication in pediatric HEV cases.
Conclusions:
The authors conclude that cholestasis is uncommon in children with HEV infection but should be considered in non-improving cases. They propose that HEV should be included in the differential diagnosis of acute cholestasis in children. The study does not suggest new diagnostic protocols but highlights the need for awareness. The authors emphasize the importance of follow-up in HEV-infected patients with jaundice. This case is the first reported from Nepal involving HEV-induced cholestasis in a child. The findings do not imply a new treatment approach but suggest a broader clinical consideration. The authors do not propose new research directions but encourage further documentation of similar cases. The report serves as a clinical reference for rare HEV complications.
The main outcome is the documentation of cholestasis in an 8-year-old child with HEV infection, a rare complication in pediatric cases.
Ultrasonography and liver biopsy were used to confirm acute hepatitis and cholestasis, while serological testing detected HEV IgM.
Cholestasis is uncommon in children with HEV, and this case highlights the need for clinicians to consider HEV in unexplained cholestatic presentations.
The child was managed symptomatically without antiviral therapy, as no specific treatment was indicated.
This case suggests that HEV should be considered in the differential diagnosis of acute cholestasis in children, especially in endemic regions.
Yes, the authors state this is the first reported case from Nepal involving HEV-induced cholestasis in a child.
