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Updated: Jul 25, 2025
Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
Small molecule fluorescent probes for the study of protein phase separation
Tze Cin Owyong1, Jiamin Zhao2, Yuning Hong2
1Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia; ARC Centre of Excellence in Exciton Science, School of Chemistry, Bio21 Institute, The University of Melbourne, VIC, 3010, Australia.
Abstract:
Liquid-liquid phase separation (LLPS) and liquid-solid phase transitions (LSPT) play crucial roles in biological systems, including sorting biomolecules, facilitate the transport of substrates for assembly, and accelerate the formation of metabolic and signaling complexes. Efforts towards improved characterization and quantification of phase separated species remain of outstanding interest and priority. In this review, we cover recent advances and the strategies used with small molecule fluorescent probes for the study of phase separation.
