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Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

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Related Experiment Video

Updated: Jul 25, 2025

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

Chapter 5.2: Oral Microbial Biofilms.

Clarissa Cavalcanti Fatturi Parolo¹, Rodrigo Alex Arthur¹

¹Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Monographs in Oral Science

|June 26, 2023

Summary

This summary is machine-generated.

The oral microbiome maintains health through microbial balance, but stressors can cause dysbiosis, increasing disease risk. Understanding these microbial interactions is key to preventing dental caries.

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Last Updated: Jul 25, 2025

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

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Published on: December 1, 2014

Oral Biofilm Analysis of Palatal Expanders by Fluorescence In-Situ Hybridization and Confocal Laser Scanning Microscopy

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Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Concurrent Quantification of Cellular and Extracellular Components of Biofilms

Published on: December 10, 2013

Area of Science:

Microbiology
Oral Health
Microbial Ecology

Background:

The oral cavity hosts a complex microbiome of bacteria, fungi, viruses, and archaea.
Microbial homeostasis, maintained by synergistic and antagonistic interactions, is crucial for oral health.
Stressors can disrupt this balance, leading to dysbiosis and increased susceptibility to oral diseases like dental caries.

Purpose of the Study:

To explore the etiology and pathogenesis of coronal dental caries.
To understand the role of oral biofilm structure and microbial interactions in caries development.
To highlight the potential of omics approaches in studying dental caries.

Main Methods:

Review of existing literature on oral microbiome composition and function.
Analysis of microbial interactions within health and cariogenic oral conditions.
Discussion of recent advances in omics technologies for microbial research.

Main Results:

A balanced oral microbiome suppresses potentially pathogenic microorganisms.
Dysbiosis, characterized by an overgrowth of pathogens, is linked to increased disease risk.
Biofilm formation is essential for the development of dental caries.

Conclusions:

Understanding the oral microbiome's composition and metabolic interactions is fundamental for developing effective preventive and therapeutic strategies for dental caries.
Studying both healthy and cariogenic states provides essential insights into the disease process.
Omics approaches offer significant potential for advancing our knowledge of dental caries.