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Updated: Jul 25, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
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Reductive Catalytic Difluorocarbene Transfer via Palladium Catalysis

Xue-Ying Zhang1, Shi-Ping Sun1, Yue-Qian Sang1

  • 1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Angewandte Chemie (International Ed. in English)
|June 26, 2023
PubMed
Summary

A novel palladium-catalyzed reaction efficiently transfers difluorocarbene from chlorodifluoromethane to form difluoromethylated arenes. This method offers a convenient and functional-group-tolerant approach for synthesizing valuable fluorinated compounds.

Keywords:
Aryl BromideClCF2HDifluoromethylationPalladium DifluorocarbeneReductive Difluorocarbene Transfer

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