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Correction to: A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation

Andrew A Monte1,2,3,4, Alexis Vest5, Julie A Reisz6

  • 1Department of Emergency Medicine, University of Colorado School of Medicine, Leprino Building, 7Th Floor Campus Box B-215, 12401 E. 17Th Avenue, Aurora, CO, 80045, USA. Andrew.monte@cuanschutz.edu.

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
|June 26, 2023
PubMed
Abstract

No abstract available in PubMed .

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
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