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Genetic and environmental influences on one-trial conditioned context aversion in mice
Çınar Furkan İlhan1, Gonzalo P Urcelay2, Sezen Kışlal1
1Department of Psychology, Middle East Technical University, Ankara, Turkey.
Genes, Brain, and Behavior
|June 27, 2023
Summary
Anticipatory nausea (AN) can be modeled in mice using conditioned context aversion (CCA). Outbred female mice showed stronger CCA retention than males, suggesting CD1 mice are a valuable model for studying AN sex differences.
Area of Science:
- Neuroscience
- Behavioral Science
- Pharmacology
Background:
- Anticipatory nausea (AN) is a chemotherapy side effect predominantly affecting female patients.
- Conditioned context aversion (CCA) in rodents models AN, but the role of prior context exposure is unclear.
Purpose of the Study:
- Develop a CCA paradigm in mice to assess context pre-exposure effects.
- Evaluate potential sex differences in CCA development and retention.
- Determine the suitability of CD1 and C57BL/6J mice for modeling AN.
Main Methods:
- Conditioned context aversion (CCA) induced by pairing a novel context with LiCl-induced illness.
- Assessment in outbred (CD1) and inbred (C57BL/6J) mice of both sexes.
- Evaluation of CCA development and retention following context pre-exposure.
Main Results:
- A single conditioning trial successfully induced CCA in CD1 mice, but not C57BL/6J mice.
- Prior context experience facilitated CCA development in CD1 mice.
- Outbred female mice exhibited longer and more robust CCA retention than males.
Conclusions:
- CD1 outbred mice serve as a suitable preclinical model for anticipatory nausea (AN).
- The CCA paradigm effectively demonstrates context pre-exposure effects and sex differences.
- Findings support further investigation of sex-based variations in AN and its preclinical modeling.
