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Updated: Jul 25, 2025

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
Published on: February 9, 2014
[Research of progress of mitochondria in the pathogenesis of sepsis]
Liwei Yu1, Zhiling Zhao, Gaiqi Yao
1Department of Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China. Corresponding author: Yao Gaiqi,
Abstract:
Sepsis is an organ dysfunction caused by dysregulation of the body's response to infection, with high morbidity and mortality. The pathogenesis of sepsis is still unclear, and there are no specific treatment drugs. As a cell energy supply unit, the dynamic changes of mitochondria are closely related to various diseases. Studies have shown that structure and function of mitochondria are changed in different organs during sepsis. The energy shortage, oxidative stress change, imbalance of fusion and fission, autophagy reduce, biological functions of mitochondria play important roles in sepsis progress, which can provide a research target for the treatment of sepsis.
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