Related Experiment Videos
Association between routine blood count-derived inflammatory markers and left ventricular hypertrophy in diabetic
1Department of General Practice, Peking University Third Hospital, Beijing, China.
Insights
In diabetic kidney disease (DKD) patients, elevated neutrophil counts and the systemic immune-inflammation index (SII) are linked to left ventricular hypertrophy (LVH). These inflammatory markers, along with uric acid and urea, predict LVH risk in DKD.
Area of Science:
- Cardiovascular complications in nephrology
- Diabetic kidney disease (DKD) research
- Biomarker discovery in cardiovascular disease
Background:
- Adverse cardiovascular events are a major complication in DKD.
- Left ventricular hypertrophy (LVH) is a significant predictor of cardiovascular events in DKD.
- Low-grade inflammation in DKD exacerbates kidney and cardiovascular damage.
Purpose of the Study:
- To investigate the association between routine blood count-derived inflammatory markers and LVH in DKD patients.
- To identify predictive markers for LVH in the peripheral blood of individuals with DKD.
Main Methods:
- Cross-sectional study involving 419 DKD patients (G2-G4).
- Patients categorized into LVH and non-LVH groups based on echocardiography.
- Logistic regression analysis used to identify factors associated with LVH; ROC curves generated for neutrophil and SII.
Main Results:
- Neutrophil count, Systemic Immune-Inflammation Index (SII), uric acid, and urea were positively correlated with LVH.
- Male gender and calcium levels were negatively correlated with LVH.
- Combined neutrophil and SII with basic variables improved LVH prediction (AUC=0.816) compared to basic variables alone (AUC=0.782).
Conclusions:
- Neutrophil count, SII, uric acid, and urea are independent positive predictors of LVH in DKD patients (G2-G4).
- Male gender and calcium levels are negative predictors of LVH in this population.
- Neutrophil and SII show potential as accessible biomarkers for LVH risk stratification in DKD.
Background:
Adverse cardiovascular events are one of the most serious complications of diabetic kidney disease (DKD), and left ventricular hypertrophy (LVH) is a reliable predictor. The low-grade inflammatory state in patients with DKD further aggravates the damage to the kidneys and cardiovascular system. This study aims to explore the relationship between routine blood count-derived inflammatory markers in the peripheral blood of DKD patients and LVH.
Methods:
In this cross-sectional study, 419 patients with DKD G2 ~ G4, who received treatment at the Peking University Third Hospital from January 2020 to September 2025 were enrolled. Based on the echocardiographic findings, the participants were categorized into two groups: those with LVH and those without. Logistic regression was employed to examine the factors associated with LVH, as well as the interactions among neutrophil, the systemic immune-inflammation index (SII), and the stages of DKD. Additionally, receiver operating characteristic (ROC) curves and the optimal cut-off values of the SII and neutrophil were generated.
Results:
Among the 419 participants included in the study, there were 239 males and 180 females, with a baseline age of 66 years. 106 individuals were categorized in the LVH group. Multivariate logistic regression analysis revealed that neutrophil (OR = 1.31, P = 0.011), SII (OR = 1.01, P = 0.011), uric acid (OR = 1.01, P<0.01), and urea (OR = 1.02, P = 0.002) are positive correlation factors for LVH. In contrast, male gender (OR = 0.33, P<0.01) and calcium (OR = 0.07, P = 0.001) serve as negative correlation factors for LVH. Furthermore, DKD stage did not significantly modify the effects of neutrophil (interaction P = 0.09) and SII (interaction P = 0.22). The area under the curve (AUC) for basic variables, which include gender, calcium, uric acid, and urea, when combined with neutrophil and SII, was 0.816. This AUC, along with that of basic variables combined with SII (0.810), exceeded the AUC of basic variables alone (0.782), with the difference reaching statistical significance (P < 0.05). The optimal cut-off value for neutrophil is 4.14×109/L, and the optimal cutoff value for SII is 491.78×109/L.
Conclusion:
In DKD G2 ~ G4 patients, neutrophil, SII, uric acid and urea sever as independent positive correlation factors for LVH. In contrast, male gender and calcium serves as negative correlation factors.
Related Concept Videos
01:28Diabetic Nephropathy
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:24Chronic Kidney Disease II: Clinical Manifestations