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A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations
Yanzhi Dou1, ZiYue Huang2, Tie Li1
1Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Chemical Communications (Cambridge, England)
|June 27, 2023
Abstract:
We developed a rapid and accurate biosensor to detect SARS-CoV-2 and distinguish its mutations. Benefitting from a DNA framework-modified ordered interface and a dual signal amplification strategy, our biosensor could detect SARS-CoV-2 with a detection limit down to 10 fM. It performed well on pseudo virus and SARS-CoV-2 RNA standard materials, revealing the potential application in disease diagnosis and spread, in combination with a home-made smartphone.
