Recent Advances in Metaphotonic Biosensors

Area of Science:

• Metasurface science
• Nanophotonics
• Biomedical engineering

Background:

• Metaphotonic devices manipulate light at the subwavelength scale, enhancing light-matter interactions for biosensing applications.
• Metaphotonic biosensors address limitations in sensitivity, selectivity, and detection limits of existing bioanalytical methods.

Purpose of the Study:

• To review various metasurface types used in metaphotonic biosensing.
• To outline prevalent working mechanisms for metaphotonic bio-detection.
• To summarize advancements in chip integration for point-of-care metaphotonic biosensing devices.

Main Methods:

• Review of literature on metasurfaces for refractometry, surface-enhanced fluorescence, vibrational spectroscopy, and chiral sensing.
• Analysis of working principles in metaphotonic bio-detection schemes.
• Summary of progress in chip integration for metaphotonic biosensing.

Main Results:

• Identified diverse metasurface types applicable to various biomolecular sensing domains.
• Detailed prevalent working mechanisms driving metaphotonic bio-detection.
• Highlighted recent progress in chip integration for point-of-care applications.

Conclusions:

• Metaphotonic biosensing shows significant promise for revolutionizing clinical diagnostics.
• Challenges remain in cost-effectiveness and handling complex biospecimens.
• Future directions focus on materializing device strategies for widespread healthcare impact.