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Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects.

Olga I Guliy1, Stella S Evstigneeva1, Vitaly A Khanadeev1

  • 1Institute of Biochemistry and Physiology of Plants and Microorganisms, Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospect Entuziastov, Saratov 410049, Russia.

Biosensors
|June 27, 2023
PubMed
Summary

Rapid virus detection is crucial due to widespread pathogens and mutations. Phage display antibodies offer a promising solution for highly sensitive, sensor-based virus detection, addressing limitations of current methods.

Keywords:
antibody phage display technologybiosensorsdetection methodsviruses

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Area of Science:

  • Virology
  • Bioengineering
  • Nanotechnology

Background:

  • Viruses are ubiquitous environmental agents causing significant plant, animal, and human diseases.
  • The constant mutation and pathogenicity of viruses necessitate rapid and sensitive detection methods.
  • Recent increases in viral disease incidence, like SARS-CoV-2, highlight the limitations of existing diagnostic tools.

Purpose of the Study:

  • To review current virus detection methods and their limitations.
  • To explore the potential of phage display technology antibodies for enhanced virus detection.
  • To assess the application of these engineered antibodies in sensor-based diagnostic systems.

Main Methods:

  • Analysis of existing literature on virus detection techniques.
  • Examination of phage display technology for antibody generation.
  • Evaluation of sensor-based detection principles utilizing bio-engineered macromolecules.

Main Results:

  • Phage display technology enables the production of specific, high-affinity antibodies.
  • These antibodies can function as sensitive recognition elements in biosensors.
  • Sensor-based detection offers a pathway to overcome limitations of conventional diagnostic methods.

Conclusions:

  • Phage display antibodies represent a powerful tool for developing next-generation virus detection systems.
  • The application of these engineered antibodies in sensors promises improved sensitivity and speed for diagnostics.
  • This approach holds significant potential for monitoring and managing viral diseases effectively.