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Related Concept Videos

Hormones and Bone Tissue01:17

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Related Experiment Video

Updated: Jul 25, 2025

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High Solubility and Bioavailability of Lobster Shell-Derived Calcium for Significantly Proliferating Bone and Skin

Trung T Nguyen1,2, Thanh Hoang1, Tuyet Pham3

  • 1College of Science and Engineering, Flinders University, Adelaide, SA 5042, Australia.

Marine Drugs
|June 27, 2023
PubMed
Summary

Lobster minerals, derived from shell waste, offer a sustainable and highly bioavailable source of calcium. These minerals demonstrate superior functional properties and promote cell growth, indicating their potential as a valuable nutraceutical ingredient.

Keywords:
bone healthlobster minerallobster shellsmicrowave-intensified extractionmulti-product biorefinerynutraceutical calciumvalue-added productswound healing

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Area of Science:

  • Biorefinery and Waste Valorization
  • Nutraceuticals and Functional Ingredients
  • Biomaterials and Cell Biology

Background:

  • Shellfish waste presents significant environmental and economic challenges for the industry.
  • Conventional chitin production methods are chemically intensive and limit co-product recovery.
  • A novel microwave-intensified biorefinery efficiently extracts chitin, proteins, and minerals from lobster shells.

Purpose of the Study:

  • To investigate the nutritional, functional, and nutraceutical potential of minerals extracted from lobster shells.
  • To evaluate the cytotoxicity and cellular effects of lobster-derived minerals on bone, skin, and immune cells.
  • To assess the suitability of lobster minerals as a functional or nutraceutical ingredient for commercial applications.

Main Methods:

  • In vitro simulated gastrointestinal digestion was employed to analyze nutritional attributes.
  • Functional properties (water retention, oil binding) were compared against commercial alternatives.
  • In vitro cell culture studies using MG-63 (bone), HaCaT (skin), and THP-1 (macrophage) cells assessed cytotoxicity, proliferation, and growth.
  • Calcium content, solubility, and in vitro bioavailability were quantified and compared to commercial calcium supplements.

Main Results:

  • Lobster minerals exhibited comparable calcium content to commercial calcium supplements, with significantly higher solubility (98.4% vs. 18.6%) and 5.9-fold greater in vitro bioavailability.
  • Incorporation of lobster minerals into beef improved water retention and oil binding capacity compared to casein and commercial calcium lactate.
  • Lobster minerals demonstrated no cytotoxicity and significantly enhanced proliferation and growth in bone (MG-63) and skin (HaCaT) cells, with notable effects at 15% supplementation.
  • Macrophages (THP-1) showed high viability (>82.2%) and no morphological changes at tested concentrations.

Conclusions:

  • Lobster minerals are a promising, highly bioavailable calcium source with excellent functional properties.
  • These minerals promote significant cellular growth and proliferation in bone and skin cells without inducing cytotoxicity.
  • Lobster minerals represent a valuable, sustainable ingredient for functional foods, nutraceuticals, and other commercial products.