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Serum total bilirubin level is associated with contrast induced nephropathy after primary percutaneous coronary

Murat Oğuz Özilhan1, Sadık Kadri Açıkgöz1

  • 1Department of Cardiology, Ankara City Hospital, Ankara, Turkey.

Angiology
|June 27, 2023
PubMed

Insights

Lower serum bilirubin levels are linked to a higher risk of contrast-induced nephropathy (CIN) in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). Bilirubin may serve as a predictive biomarker for CIN.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following angiographic procedures, particularly primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI).
  • Oxidative stress and free radical damage are implicated in the pathogenesis of CIN.
  • Bilirubin possesses antioxidant and anti-inflammatory properties, offering potential protection to endothelial cells.

Purpose of the Study:

  • To investigate the association between serum total bilirubin levels and the incidence of CIN in patients with STEMI undergoing pPCI.

Main Methods:

  • A cohort of 595 STEMI patients undergoing pPCI between January 2021 and December 2022 was analyzed.
  • Serum total bilirubin levels were measured, and the development of CIN was recorded.
  • Multivariate logistic regression analysis was employed to identify independent predictors of CIN.

Main Results:

  • 116 patients (19.5%) developed CIN.
  • Serum total bilirubin levels were significantly lower in patients who developed CIN (P = .001).
  • Lower serum bilirubin level was identified as an independent predictor of CIN, alongside age, gender, contrast volume, and white blood cell count.

Conclusions:

  • Elevated serum bilirubin levels are associated with a reduced risk of developing CIN in STEMI patients undergoing pPCI.
  • Serum bilirubin may serve as a valuable biomarker for predicting CIN risk.
  • Monitoring bilirubin levels could aid in early preventive strategies and patient follow-up for CIN.

Keywords:
ST-segment elevation myocardial infarctioncontrast induced nephropathyprimary percutaneous coronary interventionserum bilirubin

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