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Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical
Adam W Doelman1, Femke Streijger1, Steve J A Majerus2,3
1International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Biomedicines
|June 28, 2023
Summary
Animal models are crucial for understanding neurogenic bladder dysfunction after spinal cord injury (SCI). Cystometry in these models helps assess neurogenic lower urinary tract dysfunction (NLUTD) and test therapies before human trials.
Area of Science:
- Urology
- Neuroscience
- Animal Models
Background:
- Neurogenic bladder dysfunction significantly impacts morbidity post-spinal cord injury (SCI).
- Neurogenic lower urinary tract dysfunction (NLUTD) is prevalent in severe SCI, manifesting as overactivity, dyssynergia, or underactivity.
- Understanding NLUTD is vital for improving patient outcomes.
Purpose of the Study:
- To review the literature on using animal models for cystometry in SCI-related NLUTD assessment.
- To discuss the pros and cons of various animal models for studying NLUTD.
- To identify future research opportunities in this field.
Main Methods:
- Narrative review of existing literature.
- Focus on cystometry techniques in animal models.
- Analysis of different animal species used (rats, mice, cats, dogs, pigs).
Main Results:
- Animal models are essential for fundamental research and therapeutic evaluation of SCI-induced NLUTD.
- Urodynamics, specifically cystometry, is a key tool for measuring NLUTD in animal models.
- Various animal models offer different advantages and disadvantages for studying specific aspects of NLUTD.
Conclusions:
- Animal models and cystometry are indispensable for advancing the understanding and treatment of SCI-related neurogenic bladder.
- Careful selection of animal models is crucial for successful translation to human therapies.
- Further research is needed to optimize assessment tools and therapeutic strategies in preclinical models.
